Cell therapy for myocardial infarction: Special delivery
نویسندگان
چکیده
منابع مشابه
Cell Therapy for Acute Myocardial Infarction
In 1960, McCulloch and Till 1 identified a bone marrow stem cell capable of reconstituting hematopoiesis in mice, later documenting the clonality of these cells.2 The concept of the adult stem cell thus was born. More than 3 decades later, Asahara et al3 extended this concept to include the formation of vascular elements from bone marrow–derived, circulating endothelial progenitors. Although co...
متن کاملCell therapy for acute myocardial infarction.
Evidence suggesting that bone marrow and circulating blood may harbor myocardial and vascular progenitor cells was the basis for pre-clinical studies of cell therapy for acute myocardial infarction (MI). Rapid initiation of clinical trials has since followed, with regional myocardial delivery of autologous cells being tested as adjunctive therapies for both acute and chronic left ventricular dy...
متن کامل[Stem cell therapy in acute myocardial infarction].
Remodeling of the left ventricle after myocardial infarction represents a major cause of infarct-related heart failure and death. Experimental data suggest that bone marrow-derived cells may contribute to the healing of myocardial infarction. The selective intracoronary transplantation of autologous, mononuclear bone marrow cells is safe and seems to be effective under clinical conditions conce...
متن کاملCell-based therapy of myocardial infarction.
Cell-based therapy is a promising option for treatment of ischemic diseases. Several cell types have experimentally been shown to increase the functional recovery of the heart after ischemia by physically forming new blood vessels, differentiating to cardiac myocytes and--additionally or alternatively--by providing proangiogenic and antiapoptotic factors promoting tissue repair in a paracrine m...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2008
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2007.10.024